Lab meeting will take place on
Monday, April 12, 2021
10:00am ET
Virtual
Presenter:
Jaspreet Singh, Ph.D., Flatiron Research Fellow,
Developmental Dynamics
Biophysics of Arrested Cytokinesis
Cell division is often incomplete in early-stage gametogenesis: instead of separating, daughter cells remain connected through cleavage furrows that are stabilized into intercellular bridges (ICBs). While significant progress has been made in elucidating their ultrastructural and molecular composition, the dynamics of their assembly and mechanical stability is poorly understood. We develop a one kinematic variable model that accounts for geometrical nonlinearities, underlying the dynamics of transition from a parent cell to two daughter cells with an ICB. We show that precise control of contractility and furrow remodeling is essential for assembling ICBs with experimentally observed aspect ratios.
