Using a coarse-grained model of microtubule hydrodynamics to understand the transition to swirling flows

by David Stein

Friday May 14, 2021, 3:00 PM → 4:00 PM America/New_York

During the development of the fruit fly oocyte, flows with short-ranged correlations transition to a cell-spanning vortex, accompanied by coherent deformations in the microtubule cytoskeleton. This phenomenon is just one dramatic example of the many intracellular processes driven by the interactions between well aligned assemblies of slender filaments, the molecular motors that push, pull, or move along them, and the fluid that they are immersed within. While both the quantitative and qualitative behavior of such systems depends on the density of the filaments, simulations with biologically relevant filament densities are challenging, if not impossible. In this talk, I'll introduce a coarse-grained model for the hydrodynamics of ordered, immersed fibers, and show how we can use this model, along with simulations and experiments, to gain insight into the generation of system-spanning vortical flows in both the fruit-fly oocyte and confined artificial asters.

 

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