The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions. Simulation of cytoskeletal assemblies is an important tool for modeling cellular processes and understanding their surprising material properties. Here we present aLENS, a novel computational framework to surmount the limits of conventional simulation methods. We model molecular motors with crosslinking kinetics that adhere to a thermodynamic energy landscape, and integrate the system dynamics while efficiently and stably enforcing hard-body repulsion between filaments – molecular potentials are entirely avoided in imposing steric constraints. Utilizing parallel computing, we simulate different mixtures of tens to hundreds of thousands of cytoskeletal filaments and crosslinking motors, recapitulating self-emergent phenomena such as bundle formation and buckling, and elucidating how motor type, thermal fluctuations, internal stresses, and confinement determine the evolution of active matter aggregates.
Date: Friday, 11/12
Time: 3-4 pm; reception to follow 4-6 pm on the 162 roof
Location: Hybrid event (162 Fifth Avenue, 2nd floor auditorium + a Zoom option)
Hi there,
Flatiron Institute is inviting you to a scheduled Zoom meeting.
Topic: aLENS: towards the cellular-scale simulation of motor-driven cytoskeletal assemblies
Time: Nov 12, 2021 03:00 PM Eastern Time (US and Canada)
Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/96110252748?pwd=VlNjczJJQTd0alRqT2syU05aMVUwQT09
Passcode: 471397
Or Telephone:
Dial(for higher quality, dial a number based on your current location):
US: +1 646 558 8656 or +1 301 715 8592 or +1 312 626 6799 or +1 253 215 8782 or +1 346 248 7799 or +1 669 900 6833
Meeting ID: 961 1025 2748
Passcode: 471397
International numbers available: https://simonsfoundation.zoom.us/u/ab8PoaNn0t
Or an H.323 room system:
162.255.36.11 (US East)
Meeting ID: 961 1025 2748
Passcode: 471397