Aug 8 – 10, 2019
Flatiron Institute
America/New_York timezone

New Methods for Denoising and CTF Correction

Aug 8, 2019, 5:15 PM
2h
Ingrid Daubechies Auditorium (Flatiron Institute)

Ingrid Daubechies Auditorium

Flatiron Institute

162 Fifth Ave, 2nd fl. New York, NY 10010

Speaker

William Leeb (University of Minnesota)

Description

We will present recent work on the problem of simultaneously denoising cryo-EM images and correcting for the effects of the contrast transfer function (CTF). The methods used are based on new results from high-dimensional principal component analysis and matrix recovery in the spiked covariance model. We use new spectral shrinkers that account for the effects of both the CTF and the colored noise distribution. This is joint work with Joakim Andén and Amit Singer.

Primary author

William Leeb (University of Minnesota)

Co-authors

Presentation materials

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