NYC Computational Cryo-EM Summer Workshop

Session

Chair: Marin van Heel

Aug 8, 2019, 2:00 PM

Ingrid Daubechies Auditorium (Flatiron Institute)

9. Pilar Cossio; Unbiased cross-validation of cryo-EM maps

Dr Pilar Cossio

8/8/19, 2:00 PM

Cryo-electron microscopy is a revolutionary technique that can Provide 3D density maps at near atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to overfit the reconstructions to noisy data. Here, inspired by modern statistics, we develop a novel methodology that uses a small independent particle set to...

8. Jose Maria Carazo; Local Directional Resolution: Its impact in map validation, map sharpening and beyond

Dr Jose Maria Carazo

8/8/19, 2:40 PM

I will introduce the notion of Directional Local Resolution, extending the current practice in CryoEM around local resolution. In this way, local resolution becomes a tensor. I will then present the wide range of new opportunities that this extension opens, while focusing during the presentation mostly in map validation and sharpening