In recent years we have seen an avalanche of cryo-EM (cryogenic Electron Microscopy) publications presenting beautiful biological structures at resolution levels of even better than ~3Å! This true “resolution revolution” has culminated in the 2017 Nobel prize for Chemistry being awarded for single-particle cryo-EM. Impressive as these results may be (and continue to be), various fundamental -...
This talk discusses information fusion algorithms for biomolecular structure determination using data obtained from both Small-Angle X-Ray Scattering (SAXS) and Single-Particle Electron Microscopy (EM). As a precursor to information fusion, methods for cross-validation to ensure data consistency are first addressed. As such, the theories behind SAXS and EM data acquisition are both reviewed....