NYC Computational Cryo-EM Summer Workshop

Session

Chair: Yoel Shkolnisky

Aug 9, 2019, 9:00 AM

Ingrid Daubechies Auditorium (Flatiron Institute)

14. Marin Van Heel; The statistical boundary between Science Fiction and Science Fact

Dr Marin Van Heel

8/9/19, 9:00 AM

In recent years we have seen an avalanche of cryo-EM (cryogenic Electron Microscopy) publications presenting beautiful biological structures at resolution levels of even better than ~3Å! This true “resolution revolution” has culminated in the 2017 Nobel prize for Chemistry being awarded for single-particle cryo-EM. Impressive as these results may be (and continue to be), various fundamental -...

15. Gregory Chirikjian; Cross-Validating and Fusing Information from SAXS and EM

Dr Gregory Chirikjian

8/9/19, 9:40 AM

This talk discusses information fusion algorithms for biomolecular structure determination using data obtained from both Small-Angle X-Ray Scattering (SAXS) and Single-Particle Electron Microscopy (EM). As a precursor to information fusion, methods for cross-validation to ensure data consistency are first addressed. As such, the theories behind SAXS and EM data acquisition are both reviewed....