CCN

CCN Seminar - Filip Vercruysse (École Polytechnique de Lausanne)

America/New_York
4th Floor Classroom/4-Simons Foundation (160 5th Avenue)

4th Floor Classroom/4-Simons Foundation

160 5th Avenue

30
Description

Please welcome our CCN Seminar guest speaker Filip Vercruysse, Ph.D. from École Polytechnique de Lausanne (EPFL, Switzerland). Please note that the lecture will be 1 hour, and the remaining 30 minutes will be left for Q&A. Zoom credentials below for those tuning in remotely!


If you are interested in scheduling any 1:1 meetings with Filip, please reach out directly to Matthew Turner at mturner@flatironinstitute.org


Title: Self-organization of a doubly asynchronous irregular network state for spikes and bursts

Abstract: Cortical pyramidal cells (PCs) have a specialized dendritic mechanism for the generation of bursts, suggesting that these events play a special role in cortical information processing. In vivo, bursts occur at a low, but consistent rate. Theory suggests that this network state increases the amount of information they convey. However, because burst activity relies on a threshold mechanism, it is rather sensitive to dendritic input levels. In spiking network models, network states in which bursts occur rarely are therefore typically not robust, but require fine-tuning. Here, we show that this issue can be solved by a homeostatic inhibitory plasticity rule in dendrite-targeting interneurons that is consistent with experimental data. The suggested learning rule can be combined with other forms of inhibitory plasticity to self-organize a network state in which both spikes and bursts occur asynchronously and irregularly at low rate. Finally, we show that this network state creates the network conditions for a recently suggested multiplexed code and thereby indeed increases the amount of information encoded in bursts