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SUMMARY:CCB Brown Bag Seminar
DTSTART:20231102T171500Z
DTEND:20231102T183000Z
DTSTAMP:20261011T173100Z
UID:indico-event-3903@indico.flatironinstitute.org
CONTACT:dtucker@flatironinstitute.org
DESCRIPTION:1st Speaker:  Justin Lindsay\, Ph.D\, Flatiron Research Fel
 low\, Structural and Molecular Biophysics\, CCBTopic:  The Evening Comple
 x Exposed: How ELF3's Dynamics Shape Temperature Sensitivity in PlantsThe 
 "Evening Complex" (EC) modulates circadian gene expression and growth in r
 esponse to temperature in plants like Arabidopsis thaliana. This regulati
 on involves the ELF3 protein's prion-like domain (PrD)\, which undergoes l
 iquid-liquid phase separation (LLPS) influenced by a variable-length polyg
 lutamine (polyQ) repeat. Our molecular dynamics simulations reveal the cri
 tical role of polyQ in forming transient temperature-sensitive helices and
  its impact on protein secondary structure. Aromatic residues primarily di
 ctate protein contact dynamics\, with changes at higher temperatures promo
 ting aggregation. Understanding LLPS has broad implications\, from agricul
 ture to potential human disease therapies.2nd Speaker: Daniel Needleman\,
  Ph.D.\,  Senior Research Scientist\, Biophysical ModelingSenior Project
  Lead\, CCBxTopic: Measuring and modeling the dynamics of mitotic error c
 orrectionWhen functioning properly\, the mitotic spindle segregates an equ
 al number of chromosomes to daughter cells. Over the course of spindle ass
 embly\, initially erroneous attachments between chromosomes and the spindl
 e are fixed through a process called error correction. Despite the importa
 nce of chromosome segregation errors in cancer and other diseases\, we lac
 k an understanding of error correction and how it can go wrong. In this ta
 lk\, I will describe recent measurements from my group of mitotic error co
 rrection\, which can be explained by a simple coarse-grained model. This w
 ork provides a quantitative framework for understanding the dynamics of mi
 totic error correction.  \n\nhttps://indico.flatironinstitute.org/event/
 3903/
IMAGE;VALUE=URI:https://indico.flatironinstitute.org/event/3903/logo-40661
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LOCATION:7th Floor Classroom/7-Flatiron Institute (162 5th Avenue)
URL:https://indico.flatironinstitute.org/event/3903/
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