June 11, 2020
Virtual
America/New_York timezone

3D Tomography of Mitotic and Meiotic Spindles

Jun 11, 2020, 3:15 PM
45m
Stefanie Redemann, Ph.D. (Assistant Professor, University of Virginia)

Stefanie Redemann, Ph.D.

Assistant Professor, University of Virginia

Description

We have developed a novel approach of visualizing entire spindles in 3D by electron tomography and automatic microtubule segmentation. Using this approach, we can resolve single microtubules, which provides a unique perspective and offers a plethora of completely new information about the microstructure of spindles. By combining electron tomography, light microcopy, and biophysical modeling we aim to develop a detailed and unprecedented understanding of spindle assembly and chromosome segregation during meiosis and mitosis.

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