SMBP Group Meeting: Tee Udomlumleart (Stanford/CCM)

Tuesday Jun 17, 2025, 2:00 PM → 3:00 PM America/New_York

3rd Floor Classroom (162 Fifth Avenue)

Speaker: Tee Udomlumleart (Stanford)


Topic: Predictive modeling of mitotic chromosome formation 

Abstract: Proper chromosome compaction during mitosis ensures faithful transmission of genetic information. Due to genome complexity, current models for mitotic chromosome formation cannot capture structural features observed in both microscopy and sequencing data. To overcome previous computational limitations and increase model accuracy, I propose a predictive, mechanistic model of mitotic folding using GPU-accelerated molecular dynamics simulations and Bayesian optimization. This model simulates condensin-driven loop extrusion processes, then tunes condensin parameters to match experimental data. Preliminary results reproduce key mitotic features in both wild-type and condensin-mutant cells. The model’s predictive power potentially offers insight into how condensin mutations lead to chromosome misfolding and aneuploidy, a key driver of cancer. This efficient and accurate simulation pipeline provides a scalable and testable framework to deepen understanding of mitotic chromosome formation.