SMBP Group Meeting: Luke Evans (CCM)

Tuesday Sep 9, 2025, 2:30 PM → 3:30 PM America/New_York

3rd Floor Classroom (162 Fifth Avenue )

Speaker:  Luke Evans (CCM)

Topic:  Parsimonius Recovery of CryoEM Ensemble Probabilities

Abstract: Heterogeneity analysis has become a very popular area within cryo-EM. Many bespoke methods exist for estimating what protein conformations are in an experimental sample and how frequently each of these conformations show up. Here, we use a simple approach, treating the estimation as a non-parametric maximum likelihood problem, provide a quick numerical approximation along with theoretical guarantees and practical guidance in various data scenarios.