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Date: Friday, January 11, 2019
Time: 3:00 PM
Place: 162 2nd floor auditorium
Speaker: Jian Zhou, Flatiron Research Fellow, Genomics Group, CCB
Title: Learning to read the regulatory program of the genome - from sequence to chromatin, expression, and evolution
Abstract: Interpreting the noncoding genome and any known or unobserved variations in genomic sequence is an immense challenge for biology and medicine. The rapidly growing amount of functional genomic data provides a great opportunity to apply data-driven approaches to understand genomic sequence with machine learning, statistics, and artificial intelligence. Moreover, the recent development in single cell profiling techniques provides dynamic cellular contexts for understanding sequence functions. I will discuss our work on ab initio sequence-based prediction of transcription factor binding, chromatin, and gene expression, statistical approaches for single cell data exploratory analysis, and their applications to human diseases and evolution.