Spindle Working Group Meeting



ORGANIZING COMMITTEE, Daniel Needleman (Harvard University ), Michael Shelley (Flatiron Institue)

The Biophysical Modeling Group of the Center for Computational Biology is hosting its fourth annual Spindle Working Group meeting on July 13-15, 2020.  Held virtually, we hope that you might be able to “attend” and participate in the meeting.

The spindle is the cellular structure that separates chromosomes in dividing cells. Understanding it requires elucidating the complex interplay between mechanics, biochemistry, and active cellular force generators. 

We look forward to having you join us.

Camille Norrell, Coordinator
    • 9:45 AM 10:00 AM
      Welcome Remarks 15m
    • 10:00 AM 10:35 AM
      The Physics of Highly Crosslinked Filament Networks. 35m Sebastian Fuerthauer, Ph.D. (Flatiron Institute)

      Sebastian Fuerthauer, Ph.D.

      Flatiron Institute

    • 10:35 AM 11:00 AM
      Using a Coarse-grained Filament Model to Deduce the Behavior of Systems with Dense Microtubule Arrays 25m David Stein, Ph.D. (Flatiron Institute)

      David Stein, Ph.D.

      Flatiron Institute

    • 11:00 AM 11:25 AM
      Computational Methods and Models for Simulations of Spindle Positioning 25m Gokberk Kabacaoglu, Ph.D. (Flatiron Institute)

      Gokberk Kabacaoglu, Ph.D.

      Flatiron Institute

    • 11:25 AM 12:05 PM
      Stoichiometric Model of Microtubules and Motors: a Model for all Seasons 40m Reza Farhadifar, Ph.D. (Flatiron Institute)

      Reza Farhadifar, Ph.D.

      Flatiron Institute

    • 12:05 PM 1:00 PM
      Working lunch: Breakout Rooms 55m
    • 1:00 PM 1:40 PM
      Mechanisms of Kinesin-5 Motors in Spindle Bipolarity 40m Meredith Betterton, Ph.D. (University of Colorado Boulder)

      Meredith Betterton, Ph.D.

      University of Colorado Boulder

    • 1:40 PM 2:20 PM
      Lessons on Bipolar Spindle Assembly and Chromosome Biorientation from Computational Modeling 40m Chris Edelmaier, Ph.D. (University of Colorado Boulder)

      Chris Edelmaier, Ph.D.

      University of Colorado Boulder

    • 2:20 PM 3:00 PM
      Mean-field Methods for Modeling Motors and Cross-linkers During Spindle Assembly 40m Adam Lamson (University of Colorado Boulder)

      Adam Lamson

      University of Colorado Boulder

    • 10:00 AM 10:30 AM
      Ultrastructure of the K-Fiber in the Mammalian Mitotic Spindle 30m Robert Kiewisz, Ph.D. (TU Dresden)

      Robert Kiewisz, Ph.D.

      TU Dresden

    • 10:30 AM 11:00 AM
      Measuring and Modeling Kinetochore Microtubules in Human Cells 30m Will Conway (Harvard University)

      Will Conway

      Harvard University

    • 11:00 AM 11:30 AM
      Beyond K-Fibers: Investigation of MT Interactions in Mammalian Spindles 30m Gunar Fabig, Ph.D. (TU Dresden)

      Gunar Fabig, Ph.D.

      TU Dresden

    • 11:30 AM 12:00 PM
      Scaling of Cell Size and Spindle Dynamics in the Early C. elegans embryo 30m Chukwuebuka William Okafornta, Ph.D. (TU Dresden)

      Chukwuebuka William Okafornta, Ph.D.

      TU Dresden

    • 12:00 PM 1:00 PM
      Working lunch: Breakout Rooms 1h
    • 1:00 PM 1:40 PM
      Microtubule Plus-end Competition: a Race for Components 40m Zach Geisterfer (University of Wyoming)

      Zach Geisterfer

      University of Wyoming

    • 1:40 PM 2:20 PM
      Probing Aster Positioning Mechanics Using Varied Enclosure Geometries 40m Jay Gatlin, Ph.D. (University of Wyoming)

      Jay Gatlin, Ph.D.

      University of Wyoming

    • 2:20 PM 3:00 PM
      Characterizing the Emergent Phenomenon of Aster Rotation 40m Abdullah Bashar Sami (University of Wyoming)

      Abdullah Bashar Sami

      University of Wyoming

    • 10:00 AM 10:25 AM
      Biophysics of Spindle Motion 25m Hai-Yin Wu, Ph.D. (Harvard University)

      Hai-Yin Wu, Ph.D.

      Harvard University

    • 10:25 AM 10:50 AM
      Mechanics of Spindle Positioning and Orientation 25m Maya Anjur-Dietrich (Harvard University)

      Maya Anjur-Dietrich

      Harvard University

    • 10:50 AM 11:15 AM
      Mouse Meiotic Spindles: From the Physics of Spindle Structure to Chromosome Segregation Errors 25m Colm Kelleher, Ph.D. (Harvard University)

      Colm Kelleher, Ph.D.

      Harvard University

    • 11:15 AM 11:40 AM
      Biophysics of Chromosome Segregation Errors and Error Correction 25m Gloria Ha (Harvard University)

      Gloria Ha

      Harvard University

    • 11:40 AM 12:10 PM
      Nonlinear Characteristics of the Spindle Oscillation 30m Yuan-nan Young, Ph.D. (New Jersey Institute of Technology)

      Yuan-nan Young, Ph.D.

      New Jersey Institute of Technology

    • 12:10 PM 12:25 PM
      Lunch 15m
    • 12:25 PM 12:55 PM
      Dissipation and Efficiency of an Active Cytoskeletal Material 30m Peter Foster, Ph.D. (Massachusetts Institute of Technology)

      Peter Foster, Ph.D.

      Massachusetts Institute of Technology

    • 12:55 PM 1:25 PM
      Microtubule Gelation, Spindle Architecture, and Scaling 30m Jan Brugues, Ph.D. (Max Planck Institute )

      Jan Brugues, Ph.D.

      Max Planck Institute

    • 1:25 PM 2:25 PM
      Chromosome segregation in C. elegans 1h Stefanie Redemann, Ph.D. (University of Virginia)

      Stefanie Redemann, Ph.D.

      University of Virginia

    • 2:25 PM 3:10 PM
      Open Discussion 45m