Spindle Working Group Meeting



ORGANIZING COMMITTEE, Daniel Needleman (Harvard University ), Michael Shelley (Flatiron Institue)

The Biophysical Modeling Group of the Center for Computational Biology is hosting its fourth annual Spindle Working Group meeting on July 13-15, 2020.  Held virtually, we hope that you might be able to “attend” and participate in the meeting.

The spindle is the cellular structure that separates chromosomes in dividing cells. Understanding it requires elucidating the complex interplay between mechanics, biochemistry, and active cellular force generators. 

We look forward to having you join us.

Camille Norrell, Coordinator
    • 9:45 AM
      Welcome Remarks
    • 1
      The Physics of Highly Crosslinked Filament Networks. Sebastian Fuerthauer, Ph.D. (Flatiron Institute)

      Sebastian Fuerthauer, Ph.D.

      Flatiron Institute

    • 2
      Using a Coarse-grained Filament Model to Deduce the Behavior of Systems with Dense Microtubule Arrays David Stein, Ph.D. (Flatiron Institute)

      David Stein, Ph.D.

      Flatiron Institute

    • 3
      Computational Methods and Models for Simulations of Spindle Positioning Gokberk Kabacaoglu, Ph.D. (Flatiron Institute)

      Gokberk Kabacaoglu, Ph.D.

      Flatiron Institute

    • 4
      Stoichiometric Model of Microtubules and Motors: a Model for all Seasons Reza Farhadifar, Ph.D. (Flatiron Institute)

      Reza Farhadifar, Ph.D.

      Flatiron Institute

    • 12:05 PM
      Working lunch: Breakout Rooms
    • 5
      Mechanisms of Kinesin-5 Motors in Spindle Bipolarity Meredith Betterton, Ph.D. (University of Colorado Boulder)

      Meredith Betterton, Ph.D.

      University of Colorado Boulder

    • 6
      Lessons on Bipolar Spindle Assembly and Chromosome Biorientation from Computational Modeling Chris Edelmaier, Ph.D. (University of Colorado Boulder)

      Chris Edelmaier, Ph.D.

      University of Colorado Boulder

    • 7
      Mean-field Methods for Modeling Motors and Cross-linkers During Spindle Assembly Adam Lamson (University of Colorado Boulder)

      Adam Lamson

      University of Colorado Boulder

    • 8
      Ultrastructure of the K-Fiber in the Mammalian Mitotic Spindle Robert Kiewisz, Ph.D. (TU Dresden)

      Robert Kiewisz, Ph.D.

      TU Dresden

    • 9
      Measuring and Modeling Kinetochore Microtubules in Human Cells Will Conway (Harvard University)

      Will Conway

      Harvard University

    • 10
      Beyond K-Fibers: Investigation of MT Interactions in Mammalian Spindles Gunar Fabig, Ph.D. (TU Dresden)

      Gunar Fabig, Ph.D.

      TU Dresden

    • 11
      Scaling of Cell Size and Spindle Dynamics in the Early C. elegans embryo Chukwuebuka William Okafornta, Ph.D. (TU Dresden)

      Chukwuebuka William Okafornta, Ph.D.

      TU Dresden

    • 12:00 PM
      Working lunch: Breakout Rooms
    • 12
      Microtubule Plus-end Competition: a Race for Components Zach Geisterfer (University of Wyoming)

      Zach Geisterfer

      University of Wyoming

    • 13
      Probing Aster Positioning Mechanics Using Varied Enclosure Geometries Jay Gatlin, Ph.D. (University of Wyoming)

      Jay Gatlin, Ph.D.

      University of Wyoming

    • 14
      Characterizing the Emergent Phenomenon of Aster Rotation Abdullah Bashar Sami (University of Wyoming)

      Abdullah Bashar Sami

      University of Wyoming

    • 15
      Biophysics of Spindle Motion Hai-Yin Wu, Ph.D. (Harvard University)

      Hai-Yin Wu, Ph.D.

      Harvard University

    • 16
      Mechanics of Spindle Positioning and Orientation Maya Anjur-Dietrich (Harvard University)

      Maya Anjur-Dietrich

      Harvard University

    • 17
      Mouse Meiotic Spindles: From the Physics of Spindle Structure to Chromosome Segregation Errors Colm Kelleher, Ph.D. (Harvard University)

      Colm Kelleher, Ph.D.

      Harvard University

    • 18
      Biophysics of Chromosome Segregation Errors and Error Correction Gloria Ha (Harvard University)

      Gloria Ha

      Harvard University

    • 19
      Nonlinear Characteristics of the Spindle Oscillation Yuan-nan Young, Ph.D. (New Jersey Institute of Technology)

      Yuan-nan Young, Ph.D.

      New Jersey Institute of Technology

    • 12:10 PM
    • 20
      Dissipation and Efficiency of an Active Cytoskeletal Material Peter Foster, Ph.D. (Massachusetts Institute of Technology)

      Peter Foster, Ph.D.

      Massachusetts Institute of Technology

    • 21
      Microtubule Gelation, Spindle Architecture, and Scaling Jan Brugues, Ph.D. (Max Planck Institute )

      Jan Brugues, Ph.D.

      Max Planck Institute

    • 22
      Chromosome segregation in C. elegans Stefanie Redemann, Ph.D. (University of Virginia)

      Stefanie Redemann, Ph.D.

      University of Virginia

    • 23
      Open Discussion